The UFZ has a strong commitment to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. We look forward to applications from people who are open-minded and enjoy working in diverse teams.

Your contact for any questions you may have about the job:
Carolin Elisabeth Huber
carolin-elisabeth.huber@ufz.de

Please submit your application via our online portal with your cover letter, CV (please omit your photo, age, or marital status) and relevant attachments.

Closing date for applications:
31.07.2020

Place of work: Leipzig

More information about jobs at the UFZ: www.ufz.de/career

Helmholtz-Zentrum für Umweltforschung GmbH - UFZ
Permoserstraße 15
04318 Leipzig, Germany

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The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz association. Our mission: Our research seeks to find a balance between social development and the long-term protection of our natural resources.

The Department Effect-Directed Analysis is offering the following postion:

Master Thesis (m/f/x): Searching for new biomarkers of exposure to emerging chemicals in human biomonitoring

Humans are exposed to thousands of synthetic chemicals through consumer products, cosmetics, air and food every day. To assess this exposure human biomonitoring uses the analysis of human samples such as blood, urine, or tissue A particular challenge is the fact that many compounds are metabolized in the human body and the formed products are hardly available as reference standards. Within the project HBM4EU (www.hbm4eu.org) we are currently assessing human exposure to a wide range of suspect chemicals by liquid chromatography–high resolution mass spectrometry (LC-HRMS) screening techniques.

The aim of this master thesis is to generate metabolites from chemicals of interest by in-vitro incubation of chemicals with S9 liver extracts. The obtained metabolites will be identified by LC-HRMS and statistical tools for prioritization and finally searched for in human urine samples.



Your tasks:

  • Perform high-throughput in-vitro incubation experiments to mimic metabolic processes of the human body
  • Analysis of samples by LC-HR
  • Application of data analysis workflows and data interpretation
  • Ideally: contribute to the publication of Research outcome

Your profile:

  • Bachelor degree in chemistry, bioinformatics, biology/biochemistry, pharmacy,
    environmental sciences or related disciplines
  • General understanding of chromatography and mass spectrometry
  • Willingness to learn advanced data analysis in R and achieve new skills
  • Analytical thinking skills

We offer:

  • Individual supervision from colleagues with various expertise
  • Work in an interdisciplinary environment in a leading research institute
  • The opportunity to develop and discuss your own ideas
  • Flexible design of workplace and working hours
  • Excellent technical facilities and infrastructure
  • The possibility to introduce your own ideas and impulses from the beginning

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